Pathophysiology of STI Essay

Pathophysiology of STI Essay

Pathophysiology of STI Essay

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Select a sexually transmitted infection (STI) and do research on it. Write a 3-5 page paper about the condition/issue. In the paper discuss the concepts below:Pathophysiology of STI Essay

What is the pathophysiology of one STI
What is the etiology of the selected STI
What are the clinical manifestations of the selected STI
What is the treatment for the selected STI
Use 2-3 evidence-based articles from peer-reviewed journals or scholarly sources to support your findings. Be sure to cite your sources in-text and on a References page using APA format.

Title of Assignment:
Module 5: Disorders of the genitourinary system
Purpose of Assignment:
Health care providers must be aware of the issues related to sexually transmitted infections. This recent news release from the Centers for Disease Control and Prevention (CDC):
Retrieved from:
Course Competency(s):
• Determine pathophysiologic alterations that affect the reproductive and endocrine systems.Pathophysiology of STI Essay
Review information in your assigned readings to work on the assignment. The website below also has a variety of information to support your readings for the week.
Select a sexually transmitted infection (STI) and do research on it. Write a 3-5 page paper about the condition/issue. In the paper discuss the concepts below:
• What is the pathophysiology of one STI
• What is the etiology of the selected STI
• What are the clinical manifestations of the selected STI
• What is the treatment for the selected STI

Use 2-3 evidence-based articles from peer-reviewed journals or scholarly sources to support your findings. Be sure to cite your sources in-text and on a References page using APA format.
Need help finding evidence-based articles? Use this link:
Visit this link for an example of how to cite a video:
Have questions about APA formatting? Visit the online APA guide:

Grading Rubric:
Levels of Achievement
Criteria Emerging Competence Proficiency Mastery
(15 pts)
Did not include discussion on the pathophysiology of one STI.
Failure to provide the pathophysiology will result in zero points for this criteria. Briefly identified the pathophysiology of the one STI. Clearly identified the pathophysiology of one STI. Thoroughly identified the pathophysiology of one STI
Points: 10 Points: 13 Points: 14 Points: 15
(15 pts)
Did not include discussion on the etiology of selected STI.
Failure to provide the etiology will result in zero points for this criteria. Briefly discussed included etiology of the selected STI. Clearly discussed etiology of selected STI. Thoroughly discussed etiology of selected STI.
Points: 10 Points: 13 Points: 14 Points: 15
Clinical Manifestation
(10 pts) Did not provide examples of the clinical manifestations of the selected STI.Pathophysiology of STI Essay
Failure to provide clinical manifestations will result in zero points for this criteria. Briefly provided clinical manifestations of selected STI. Clearly provided clinical manifestations of selected STI. Thoroughly provided clinical manifestations of selected STI.
Points: 6 Points: 8 Points: 9 Points: 10
(5 pts) Did not present treatment for the selected STI.
Failure to provide treatment for selected STI will result in zero points for this criteria. Briefly provided treatment options for the selected STI. Clearly provided treatment options for the selected STI. Thoroughly provided detailed treatment for the selected STI.
Points: 2 Points: 3 Points: 4 Points: 5
APA, Spelling and Grammar
(5 pts)
Six or more APA, spelling or grammar errors. Detracts from the readability of the submission. No more than five APA, spelling or grammar errors, minimally detracts from the readability of the submission. No more than three APA, spelling or grammar errors. Does not detract from the readability of the submission. No APA, spelling or grammar errors.
Points: 2 Points: 3 Points: 4 Points: 5
Points: 30 Points: 40 Points: 45 Points: 50

Sexually transmitted diseases (STDs) are transmitted via the mucous membranes of the vagina, penis, urethra or rectum, during sexual contact with an infected individual. Transmission can also occur via membranes of the throat, respiratory tract, mouth and eyes.Pathophysiology of STI Essay

The mucous membranes are thinner than skin and allow microbes to cross them into the body. In addition, minor breaks in the skin and mucous membranes due to abrasions or cuts further increase the risk of infection. The microbes are often present in fluids secreted from the penis, vagina, saliva, faeces, urine and sweat. Sometimes, only a small amount of the microbes can lead to transmission of an STD.

Any sexual contact including oral sex and deep kissing can lead to the transmission of certain infections, although the concentration of the microbes is often lower in saliva than in the genital fluids. Non-sexual contact such as hugging and shaking hands is not usually responsible for transmitting infection.

Causative agents of STDs
The causative agents of STDs include bacteria, fungi, protozoa and viruses.Pathophysiology of STI Essay

Some of the more common types of infection include:

Bacterial infections
This is one of the most common STDs. There are often no symptoms of the infection but symptoms that may manifest in women include pain, vaginal discharge, bleeding and pain during or after sexual intercourse and a burning sensation while urinating. In men, it can cause a white, cloudy or thin, watery discharge from the tip of the penis along with pain during urination or sex. If left untreated, this infection may lead to infertility.

This is a bacterial infection that can be transmitted through any sort of unprotected sex. While often symptomless, in women, the infection may lead to pain, vaginal discharge (watery, yellowish or green), bleeding and pain during or after sexual intercourse and a burning sensation while urinating. In men, it can cause a watery, yellowish or green discharge from the tip of the penis along with pain during urination or sex. The infection may also affect the throat, eyes or rectum.Pathophysiology of STI Essay

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This is a bacterial infection that has several phases of development. In the first stage, highly infectious sores on the genitalia or mouth develop and persist for up to 6 weeks. During the next stage, a rash, fever, and hair loss may occur but subside in a few weeks. In the late stage or tertiary stage, which may occur years after the first two phases, there may be serious destructive infection of the nervous system that can lead to paralysis and blindness.

Viral infections
Herpes is caused by the herpes simplex virus. The infection causes painful, itchy blisters or sores to develop around the genital area that make sexual intercourse and urination painful. The blisters may subside and remain absent for a while, before flaring up again.Pathophysiology of STI Essay

Viral warts
These are painless but itchy warts that develop across the genitalia as a result of human papilloma virus (HPV) infection. Certain strains of HPV infection can eventually lead to cervical cancer but most infections pass without any symptoms.

HIV infection
The HIV virus attacks and damages the body’s immune system. The symptoms may take a long time to appear, with affected individuals often unaware they have the infection and therefore at risk of unknowingly passing the virus onto other people through unprotected sex. Other modes of transmission include needle sharing, blood transfusion, or mother-to-baby transmission during childbirth.

Parasitic infestations
Trichomonas vaginalis
This is caused by a parasite that is transmitted during unprotected sex. In women, the infection leads to pain and a frothy, yellow or watery vaginal discharge. In men, there may be a burning pain or no symptoms at all.Pathophysiology of STI Essay

Lice or crabs
Pubic lice can also spread via unprotected sexual contact. These lice can also live in underarm hair, body hair and beards.

In the history of sexually transmitted infection (STI) control, as with other communicable diseases, the pendulum swings between vertical disease-specific and broader horizontal approaches, from a narrow focus on pathogens and their treatment to the wider needs of populations who host and transmit them.Pathophysiology of STI Essay

Since the emergence of HIV in the 1980s, STI control efforts have increasingly been defined in relation to HIV programme priorities.1 Although HIV is itself an STI, efforts to prevent its transmission are largely managed through programmes that are funded, implemented and evaluated independently of other STI control efforts. Such a fractured paradigm has had unfortunate consequences. Too often, neglected STI programmes – the foundation upon which HIV prevention efforts were built – collapse due to reduced funding. As a result, STI clinics and services are understaffed, understocked or disappearing altogether; pregnant women may be offered HIV tests but are no longer screened for syphilis; and STI reporting, an important marker of sexual transmission trends, has largely collapsed. Pathophysiology of STI Essay

In other areas of communicable disease control, the pendulum is moving in a different direction towards strategies that aim for broad public health benefit while pursuing disease-specific control objectives. Examples include attention to general lung health within the Stop TB partnership and integrated vector management in malaria efforts. The rationale is that sustainable disease control requires coordinated efforts to address common conditions that may facilitate transmission or impede access to prevention, case detection, diagnosis and treatment.4,5

This paper describes a unified paradigm of STI control where HIV is an important focus. The approach is analytical and programme-oriented, with attention to public health outcomes and means. We start by reviewing definitions and outlining basic components of STI control, and then examine empirical evidence of the feasibility and benefits of STI control under different conditions. We also consider what happens to HIV under different scenarios and look at the overlap and potential synergies between HIV prevention and STI control efforts.Pathophysiology of STI Essay

Defining STI control
STI control is a public health outcome, measured as reduced incidence and prevalence, achieved by implementing strategies composed of multiple synergistic interventions. In the literature, the term “STI control” is frequently used interchangeably with “STI treatment”, yet these are quite different things.6,7 Control of any communicable disease is a public health outcome, measured as reduced prevalence (total infections) or incidence (new infections) in a population. Treatment is a biomedical intervention that, unless part of a broader control strategy, usually does not result in lower transmission rates or disease burden.

STI control can be measured in absolute or relative terms, for example, as elimination of chancroid or 50% reduction of the prevalence of gonorrhoea. Monitoring trends of common curable STIs, etiologically or syndromically, can provide evidence of changing incidence. Where STI surveillance is supported and functioning (often it is not), these data also reflect general sexual transmission trends and can be used to assess the adequacy of overall STI/HIV prevention efforts.8 Since HIV shares many aspects with other STIs – including modes of transmission, behavioural and other cofactors and potential control measures – HIV prevention can logically be situated within the larger, encompassing domain of STI control.Pathophysiology of STI Essay

Back to basics
A comprehensive STI control strategy includes targeted community-based interventions, promotion and provision of the means of prevention and effective clinical services within an enabling environment, as well as reliable data to guide the response.

The science and methods of STI control build on several centuries’ experience backed by evidence of progressively declining incidence and prevalence, particularly in developed countries.9 Over the past three decades, these methods have been adapted and are proving valid in some less-developed countries with limited resources. They have also been adapted to better address chronic viral STIs such as herpes simplex virus type 2 and HIV. In many countries, however, such proven control methods have not been implemented consistently or at sufficient scale to have public health impact.Pathophysiology of STI Essay

The effectiveness of standard STI control interventions and strategies – from condom promotion to epidemiologic targeting and partner treatment – is supported by extensive empirical evidence. Despite limited data from randomized controlled trials, most have been adapted to form the basis for HIV prevention work. Recent calls for “combination HIV prevention” and “back to basics” approaches to HIV emphasize the use of combinations of feasible and proven interventions.10,11

A recent review listed priority STI control interventions to include “STI treatment of high-risk sub-populations, comprehensive case management of symptomatic STIs, antenatal syphilis screening and treatment and ophthalmia neonatorum prophylaxis, condom promotion and risk reduction counselling” with increased emphasis on the role of STI clinics in identifying and counselling HIV-infected persons and in diagnosing and managing their STIs.12 The review pragmatically provides evidence for the effectiveness of individual intervention components within the fragmented domains of STI control and HIV prevention, while making a case for better alignment of efforts.Pathophysiology of STI Essay

What would such aligned control efforts include? Historical experience argues for coordinated effort in five main areas: (i) appropriate epidemiologic targeting; (ii) primary prevention and access to means of prevention; (iii) provision of effective clinical services to shorten the duration of infectivity; (iv) an “enabling environment” for prevention; and (v) reliable data to guide decision-making.

Clinical services
Clinical interventions can be broadly categorized as STI management approaches for symptomatic patients, screening for asymptomatic infections and partner strategies. All should be supported by appropriate efforts to educate, counsel and provide the means, such as condoms, to prevent infection.Pathophysiology of STI Essay

STI case management aims to provide rapid and effective treatment to patients presenting with symptoms to break the chain of infection. Shortening the duration of infectivity is an important objective in the control of STI epidemics. There is strong evidence that syndromic case management is an effective approach for patients with urethral discharge and genital ulcers. It has advantages over previous approaches (i.e. etiologic and clinical diagnosis) in most service delivery settings.12,13 Syndromic case management also performs well for common vaginal infections although it is not designed to detect asymptomatic cervical infections. STI screening and case finding are time-tested approaches for identifying asymptomatic infections. Although feasible, screening to detect cervical infection remains problematic since sensitive tests for detecting gonorrhoea and chlamydial infection remain too expensive for widespread use.

Breaking the chain of infection also involves treating as many sexual partners of people with STIs as can be identified. Several partner treatment strategies have been described with success rates as high as 30–50% (of index patients).14 Due to frequent uncertainty about STI diagnoses in women and potentially serious social consequences of notification, partner strategies should focus on identifying symptomatic men who should then be offered counselling and assistance with notifying their partners.Pathophysiology of STI Essay

Other interventions aim to interrupt transmission through epidemiologic targeting and presumptive treatment. Asking STI patients about the location of recent contacts can help direct prevention efforts to epidemiologically important “hot-spots” where incidence may be high. Presumptive treatment has been used to rapidly reduce STI prevalence among populations at highest risk, such as sex workers.15

A relatively new area for STI clinical services is identification and early intervention with people living with HIV, particularly those recently infected. Promising interventions include early HIV testing and counselling of STI patients, detection of acute HIV infection and regular STI screening and treatment to reduce genital viral load.16 It is important that clinical interventions be seen as an extension of prevention work in the community and, as such, reinforce prevention messages and promote condoms.

Primary prevention
STI control cannot be achieved by means of clinical interventions alone. Primary prevention interventions at the clinic and outside, where transmission takes place, are required. Such interventions emphasize the means of prevention, information and referrals to clinical services.11,17 There is strong evidence that male latex condoms reduce transmission of HIV by at least 80–85%, are effective against most other STIs and reduce the risk of unintended pregnancy.18 Other barrier methods, such as the female condom, may have advantages over the male condom in some situations, or as backup methods.Pathophysiology of STI Essay

From the perspective of the STI control programme, the challenge is to make condoms and other means of prevention available and affordable, promote their use and reduce barriers to utilization. Social marketing has proven effective in increasing supply and demand.21 Maximizing the public health benefit of the condom component of the programme is not simply a question of promotion and distribution in the community at large, however. What matters most is that condoms are used in situations where STIs are most likely to spread.22

There is some evidence that other behavioural interventions can be synergistic to targeted condom promotion. In Thailand, explicit messages to men about the risks of STIs from unprotected commercial sex resulted in higher reported condom use, lower reported numbers of sex worker visits and lower infection rates.22 Behaviour change in the general population, such as delaying sexual debut, may also serve to reduce transmission but there is little evidence to support abstinence or monogamy as stand-alone strategies.Pathophysiology of STI Essay

Targeting high-risk populations
Primary prevention and clinical services contribute synergistically to STI control. The success of these efforts depends not on reaching all people but on reaching the right people with effective interventions. If there is a fundamental tenet of STI control, it is that transmission depends on high rates of sexual partner change. Epidemics are sustained “upstream” in relatively small sub-groups of the population where rates of sexual partner change are sufficient to sustain high incidence (Fig. 1). Secondary or “downstream” transmission accounts for infections among people at lower risk. An important corollary is that prevention efforts that effectively reduce transmission in the high-partner “core” population are necessary, and often sufficient, to reduce transmission in the population at large.Pathophysiology of STI Essay

Fig. 1. Dynamics of STI and HIV transmission
Fig. 1. Dynamics of STI and HIV transmission
STI, sexually transmitted infection.
This principle is implemented through appropriate targeting of STI control interventions. In Asia, for example, STI control programmes increasingly aim for “saturation coverage” of high-risk populations of sex workers, men who have sex with men, and persons injecting drugs. Other interventions target bridge populations – such as clients and partners of high-risk individuals – through STI clinics or workplace interventions.

Targeting generally builds on two methods – outreach and peer interventions. Programmes begin with mapping to locate and estimate sizes of target populations.23 Contacts made during this formative stage provide the initial building blocks for peer-based interventions. Peer workers have been shown to be most effective in catalysing change in their communities, from condom use to clinic attendance to structural changes.Pathophysiology of STI Essay

Related and important concepts are structural interventions and creating an enabling environment. Structural interventions address root causes of problems, such as the difficulties of individual sex workers to negotiate condom use. By shifting responsibility from the individual to the establishment – in this case by requiring sex work establishments to enforce 100% condom use – better compliance can be achieved and monitored.22 Other examples of structural interventions include collective action by sex workers to change social conditions that put them at risk.25

Such efforts aim to create an enabling environment for prevention. STIs spread most easily among marginalized populations that live with daily risk, have little power to negotiate safer conditions and have poor access to health services. Recent successful examples of STI control have integrated basic prevention components – targeted provision of condoms and STI services – into broader community-based efforts for enabling structural change.Pathophysiology of STI Essay

Measuring STI control
STIs are reliable markers of HIV transmission that should be monitored to assess effectiveness of combined prevention efforts. Feasible methods, based on case reporting and periodic surveys, can identify areas where STI control is poor and provide outcome data needed to monitor programme performance. Surveillance should be based on routine STI case reporting, supplemented with special surveys of STI and HIV prevalence, assessment of STI syndrome etiologies, antimicrobial resistance monitoring and risk behaviour prevalence. It is also important to monitor coverage of STI services, particularly for priority population groups.

STI surveillance is a recommended component of second-generation HIV surveillance. Trends of short-duration STIs are more sensitive indicators of high-risk sexual activity than those based on HIV prevalence and can be monitored widely, even in underserved areas where STI control is often poor. Yet few countries maintain systems to collect and use such data.Pathophysiology of STI Essay

Empirical evidence
STI control outcomes
STI control has been shown to be feasible in a wide range of countries at different levels of development. STI trends have been on the decline since the early twentieth century in many developed countries and increasingly in resource-constrained countries. For example, China, Cuba and Sri Lanka documented large reductions of STIs in the 1950s and 1960s. STI control is relative and dynamic, however, and sensitive to social and economic change. STI rates surged in western Europe and North America following introduction of hormonal contraception and in China following economic liberalization.Pathophysiology of STI Essay

More recently, several countries in Asia have documented large reductions in common STIs. Thailand measured a 95% drop in common curable STIs during the 1990s following introduction of the 100% condom use programme implemented by STI clinic staff working with sex work establishments. Chancroid was quickly eliminated, congenital syphilis has become rare and maternal syphilis is stable at about two cases per 1000 pregnant women.30 Cambodia measured large decreases in both ulcerative and non-ulcerative STIs over five years following a similar intervention.22,31

In Africa, STI control efforts have been relatively neglected and STI surveillance is generally inadequate to reliably depict trends. However, several exceptions, where STI control programmes and surveillance have been maintained, provide examples of the feasibility of improving STI control even where resources are limited. Senegal, where sex work is decriminalized and STI services are accessible to sex workers, has reported moderately low and stable STI prevalence.32,33 In Nairobi, Kenya, targeted interventions with sex workers and improved STI case management in health centres preceded declines in ulcerative and other STIs and local disappearance of chancroid.Pathophysiology of STI Essay

The scale of decline in STI rates in these examples is noteworthy. Declines of 90% or more in incidence of one or more common curable STIs have been documented in China, Kenya (Nairobi), Sri Lanka and Thailand with rapid elimination of chancroid and congenital syphilis in most settings.28,30,35 In comparison, intervention trials evaluating STI treatment approaches or limited STI control interventions, have reported much lower STI reductions.36–38

HIV prevention outcomes
Evidence supporting the role of STIs as HIV cofactors is extensive and indisputable. Reducing STI prevalence removes cofactors, making HIV transmission less efficient. Countries with poor STI control have been most vulnerable to HIV epidemics, while improvements in STI control parallel or precede declines in HIV incidence and prevalence. There is growing evidence that countries that control STIs are more likely to halt and reverse their HIV epidemics than those that do not. This observation builds on an extensive body of observational and historical evidence which documented: (i) strong associations between several individual STIs and HIV; and (ii) susceptibility of countries with poor STI control to developing sizable HIV epidemics.Pathophysiology of STI Essay

More recently, several countries have reported large changes in STI incidence and/or prevalence. Cambodia, Kenya (data from Nairobi) and Thailand show HIV epidemics stabilizing and reversing in both high-risk and general population groups coincident with or following STI reductions. Sri Lanka had established good STI control before the introduction of HIV and its HIV epidemic has remained low-level for more than two decades. Despite a long-standing civil war and an uncircumcised male population, there is little evidence of transmission within the population and most cases of HIV are found among migrant labourers returning from abroad. The experience of China illustrates how deteriorating STI control since economic liberalization in the 1980s preceded a rapidly increasing HIV epidemic.28,29

Implications for programmes
What are the implications for STI control and HIV prevention programmes? If broader STI control is important for HIV prevention, how can this be achieved? What are the conditions where investment in STI control is most likely to contribute to slowing HIV epidemics? Table 1 follows standard epidemiological parameters of disease control to address these questions.Pathophysiology of STI Essay

Table 1. Epidemiologic parameters for control of STIs including HIV
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STI control efforts should focus on core and bridge populations, symptomatic patients and persons living with HIV. High coverage of such key populations as sex workers and men who have sex with men is the first priority.39,40 Efforts should also be made to reach actual or likely clients of sex workers and other bridge populations who disseminate STIs from core networks to the general population. Clinics providing STI treatment are a good entry point to screen and identify persons living with HIV, and additional effort is required to screen persons living with HIV under care to ensure that any STIs are detected and treated.16,41,42

Interventions that reduce STI prevalence will reduce the respective cofactor effect and blunt the efficiency of HIV transmission. Data and modelling have established that ulcerative STIs, particularly chancroid, herpes simplex virus type 2 and syphilis, are the most important STI cofactors for HIV transmission.43,44 Control of curable genital ulcers – chancroid and syphilis – is highly feasible and correlates well with stabilization of HIV epidemics.Pathophysiology of STI Essay

Identification of high-risk populations generally requires a two-stage process: (i) identification of epidemiologic “hot-spots” where risk is present and/or transmission is believed to be taking place; and (ii) mapping of populations in those areas. The importance of STI surveillance in this first stage of mapping has been demonstrated.49,50

Modelling has helped in understanding the potential contribution of STI control to HIV prevention at different phases of STI and HIV epidemics. Two conclusions are apparent, that STI control is most effective in preventing HIV transmission: (i) when STIs, particularly ulcers, are poorly controlled; and (ii) early in HIV epidemics. It thus makes sense to strengthen STI control rapidly when prevalence is found to be high or increasing. However, monitoring STI trends requires reliable surveillance, which is lacking in many countries.Pathophysiology of STI Essay